Alcohol Modulation of Extra-synaptic Gamma-aminobutyric Acid Type A Receptors
نویسندگان
چکیده
منابع مشابه
Alcohol Modulation of Extra-synaptic Gamma-aminobutyric Acid Type A Receptors
Development of effective treatment agents for the alcohol use disorders requires the detailed understanding of molecular targets of alcohol in the brain. The gamma-aminobutyric acid type A receptors (GABAARs) are the major molecular targets of alcohol in the central nervous system. Mediating inhibitory neurotransmission upon GABA binding in the vertebrate central nervous system, GABAARs are het...
متن کاملAdaptation of gamma-aminobutyric acid type A receptors to alcohol exposure: studies with stably transfected cells.
We studied the adaptation of gamma-aminobutyric acid type A (GABAA) receptor function to chronic ethanol exposure in cells stably transfected with the following GABAA receptor subunits: alpha-1 beta-2 gamma-2L, alpha-1 beta-2 gamma-2S, alpha-1 beta-3 gamma-2S, alpha-1 beta-1, alpha-5 beta-3 gamma-3 and alpha-6 beta-3 gamma-2S. Chronic exposure to ethanol resulted in a decrease in muscimol-stimu...
متن کاملgamma-Aminobutyric acid, acting through gamma -aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus.
Most of the actions of neurosteroids on the central nervous system are mediated through allosteric modulation of the gamma-aminobutyric acid type A (GABA(A)) receptor, but a direct effect of GABA on the regulation of neurosteroid biosynthesis has never been investigated. In the present report, we have attempted to determine whether 3beta-hydroxysteroid dehydrogenase (3beta-HSD)-containing neuro...
متن کاملMutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor?
Alcohols in the homologous series of n-alcohols increase in central nervous system depressant potency with increasing chain length until a "cutoff" is reached, after which further increases in molecular size no longer increase alcohol potency. A similar phenomenon has been observed in the regulation of ligand-gated ion channels by alcohols. Different ligand-gated ion channels exhibit radically ...
متن کاملCross-talk between P2X4 and gamma-aminobutyric acid, type A receptors determines synaptic efficacy at a central synapse.
The essence of neuronal function is to generate outputs in response to synaptic potentials. Synaptic integration at postsynaptic sites determines neuronal outputs in the CNS. Using immunohistochemical and electrophysiological approaches, we first reveal that steroidogenic factor 1 (SF-1) green fluorescent protein (GFP)-positive neurons in the ventromedial nucleus of the hypothalamus express P2X...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Periodicals of Engineering and Natural Sciences (PEN)
سال: 2016
ISSN: 2303-4521
DOI: 10.21533/pen.v4i1.48